Prince Frederik of Luxembourg, son of Prince Robert and Princess Julie, passed away on March 1, 2025, with news of his death announced recently. He was a member of the Grand Ducal Family and founded the POLG Foundation to advance research on PolG mitochondrial disease, the rare genetic condition that led to his passing.
Here’s what we know so far about Prince Frederik of Luxembourg’s death.
Prince Frederik of Luxembourg cause of death explained
Prince Frederik of Luxembourg, son of Prince Robert and Princess Julie, has died at 22 from PolG mitochondrial disease.
His father announced the news on the POLG Foundation website, an organization Frederik founded to support research. “It is with a very heavy heart that my wife and I would like to inform you of the passing of our son,” Prince Robert wrote, stating that Frederik died on March 1 in Paris.
Frederik was born with PolG mitochondrial disease but was not diagnosed until age 14 when his symptoms worsened. The United Mitochondrial Disease Foundation describes PolG as a genetic disorder caused by mutations in the POLG gene. It affects multiple organs, including the brain, muscles, and liver. The disease has no cure, though treatments can manage symptoms.
Prince Robert stated, “Because POLG disease causes such a wide range of symptoms and affects so many different organ systems, it is very difficult to diagnose and has no treatments much less a cure.”
The day before his passing, on Rare Disease Day, Frederik spoke with his family, including his siblings Alexander and Charlotte. “After gifting each of us with our farewells – some kind, some wise, some instructive – in true Frederik fashion, he left us collectively with a final long-standing family joke,” Prince Robert wrote. “Even in his last moments, his humour, and his boundless compassion, compelled him to leave us with one last laugh….to cheer us all up.”
Prince Robert called Frederik the family’s “superhero” and highlighted his work with the POLG Foundation. “Part of his superpower was his ability to inspire and to lead by example.” Frederik helped design the foundation’s branding, launched an MITO clothing line with support from Donna Karan, and contributed to research by developing mouse models and cell lines in Switzerland, the U.S., and Europe.
Originally reported by Vritti Johar on ComingSoon.net.
